Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
Jul-29-2007
Asthma is caused by a combination of poorly understood genetic and environmental factors. We have systematically mapped the effects of single nucleotide polymorphisms (SNPs) on the presence of childhood onset asthma by genome-wide association. We characterized more than 317,000 SNPs in DNA from 994 patients with childhood onset asthma and 1,243 non-asthmatics, using family and case-referent panels. Here we show multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P?value of P?10-12. In independent replication studies the 17q21 locus showed strong association with diagnosis of childhood asthma in 2,320 subjects from a cohort of German children (P = 0.0003) and in 3,301 subjects from the British 1958 Birth Cohort (P = 0.0005). We systematically evaluated the relationships between markers of the 17q21 locus and transcript levels of genes in Epstein–Barr virus (EBV)-transformed lymphoblastoid cell lines from children in the asthma family panel used in our association study. The SNPs associated with childhood asthma were consistently and strongly associated (P?10-22) in cis with transcript levels of ORMDL3, a member of a gene family that encodes transmembrane proteins anchored in the endoplasmic reticulum. The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.
Tune-Up Your Asthma
Jul-30-2007
Now is the time to tune-up your asthma, or your child's asthma, before autumn and cold/flu season arrives. Viral infections, such as the common cold, are the most common trigger...
Tune-Up Your Asthma
Jul-30-2007
Now is the time to tune-up your asthma, or your child's asthma, before autumn and cold/flu season arrives.
Asthmatic children's camp opens Aug. 9 near Uniontown
Jul-30-2007
The American Respiratory Alliance of Western Pennsylvania will offer its Camp Huff-n-Puff for children with asthma from Aug.
Dairy diet may prevent asthma
Jul-30-2007
Milk is high in fats Young children who regularly eat products containing milk fat are less likely to develop asthma, research suggests.
Chemicals can make asthma worse
Jul-29-2007
"Once you've identified them, it's important not to use them"
Many people with asthma thought they were at least safe indoors. That may not be the case.
Electronic smog linked to respiratory disease, study shows.
Jul-29-2007
Electrical fields from computers, televisions and other everyday equipment can give people asthma, influenza and other respiratory diseases, a startling new study suggests.
Skin problem linked to 3 allergies
Jul-30-2007
These people may develop any or all of three closely linked allergic conditions: atopic dermatitis, asthma, and hay fever .